Effect of stratum corneum stripping on skin penetration of drug.
نویسندگان
چکیده
منابع مشابه
Properties of adhesive tapes used for stratum corneum stripping
The effectiveness of three adhesive tapes, 3M’s No. 810, No. 845 and No. 850, in stripping stratum comeum from hairless mouse skin. was compared by measuring transdermal water loss (TEWL) and distribution profiles of a marker, minoxidil, from a solution formulation. While No. 850 tape failed to increase TEWL perceptively even after 24 strippings, both No. 810 and 845 tapes effectively removed t...
متن کاملSkin diseases associated with the depletion of stratum corneum lipids and stratum corneum lipid substitution therapy.
The skin is the largest organ of the body, whose main function is to protect the body against the loss of physiologically important components as well as harmful environmental insults. From the inside to the outside, the skin comprises three major structural layers: the hypodermis, the dermis and the epidermis. The epidermis contains four different sublayers, the stratum corneum (SC), stratum g...
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The skin is the largest organ of the body, whose main function is to protect the body against the loss of physiologically important components as well as harmful environmental insults. From the inside to the outside, the skin comprises three major structural layers: the hypodermis, the dermis and the epidermis. The epidermis contains four different sublayers, the stratum corneum (SC), stratum g...
متن کاملOvercoming the stratum corneum: the modulation of skin penetration. A review.
It is preferred that topically administered drugs act either dermally or transdermally. For that reason they have to penetrate into the deeper skin layers or permeate the skin. The outermost layer of the human skin, the stratum corneum, is responsible for its barrier function. Most topically administered drugs do not have the ability to penetrate the stratum corneum. In these cases modulations ...
متن کاملSkin barrier function and stratum corneum hydration
Under normal circumstances, epidermis must be as impermeable as possible except for a small amount of water loss to hydrate the outer layers of the SC. Although all living cells require water to function, some “dead” cells also require water to be metabolically active. As it is the case of corneocytes, epidermis must retain sufficient water to (a) hydrate the outer layers of the SC to maintain ...
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ژورنال
عنوان ژورنال: JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
سال: 1988
ISSN: 0021-9592,1881-1299
DOI: 10.1252/jcej.21.544